1/ Black seed oil for menopausal symptoms: ‘In another study, premenopausal women underwent the following protocol: 12-week administration of NS-powder capsules (1,600 mg/day), a 2-week washout period, and 12-week administration of a placebo, and vise versa. The authors of the study concluded that NS could help to control weight gain, the lipid profile, and the blood glucose and hormonal levels [58]. According to a clinical trial by Najmi et al, NS (500 mg/day) after 8 weeks was able to improve the efficacy of the therapeutic protocol (metformin + atorvastatin + aspirin) in patients with metabolic syndrome and poor glycemic control so that NS-treated patients indicated significant improvements in their FBG, postprandial blood glucose (PPBG), haemoglobin A1c (HbA1c), and LDL-C levels [59].’
2/ Black seed oil for weight loss and curbing metabolic syndrome (fat accumulation abdominally): ‘The effects of NS and TQ on different components of metabolic syndrome and cardiovascular disease risk factors, including high BP, obesity, dyslipidemia, and high blood glucose, have been established [21]. The clinical uses of NS and TQ in the prevention and treatment of these factors will be discussed in subsequent subsections.’
3/ Black seed oil for hypertension
‘Hypertension (HT) is a lifestyle-related disease, and dietary modifications are effective for its management and prevention. In a study performed by Dehkordi and Kamkhah, which evaluated the anti-hypertensive effect of NS, the intake of NS extract (200 or 400 mg/day) for 2 months was reported to decrease both the systolic and the diastolic BP in patients with mild HT as compared with the baseline and the placebo values [38]. Another study by Huseini et al on healthy volunteers who received NS oil (5 mL/day) for two months revealed the hypotensive effect of NS, with the systolic and the diastolic BP being lowered significantly as compared with both the placebo and the baseline values [31].’
4/ Black seed oil for dyslipidemia (for heart health):
‘A large RCT compared the effects of simvastatin (10 mg/day) alone and concurrent with NS seeds (500 mg/day) and garlic oil (0.625 mg/day) on the lipid profile in 258 patients with hyperlipidemia over an 8-week treatment [71]. In that study, a comparison of mean values between the two treatment groups indicated a highly significant difference (P = < 0.01) for cholesterol, TG, non-HDL, and LDL reductions and a significant difference (P = 0.03) for HDL elevation [71]. Sabzghabaee et al reported that the TC, LDL, and TG serum levels in hypercholesterolemic patients who took NS at 2 g/day for 4 weeks decreased significantly [72]. The uses of NS extract at 200 and 400 mg/day for 2 months were also reported to have decreased both the total and the LDL cholesterol in patients with mild HT as compared with the baseline [38].’
5/ Black seed oil dramatically helps with diabetes:
‘DM is characterized by chronic elevation of blood glucose, which is a central factor in the production of reactive oxygen species (ROS) that, in turn, promote cellular damage and contribute to the development and progression of diabetic complications [76]. In a report by Heshmati et al, although the administration of NS oil at 3 g/day for 12 weeks was stated to have caused insignificant decreases in the BMI, insulin level, and insulin resistance, as well as an increase in the HDL-C level, in patients with type 2 diabetes, the FBS, TG, LDL-C, and HbA1c levels were observed to have been lowered significantly in the intervention group as compared to the placebo group [77].’
6. /Holy heck. Black seed oil shows dramatic improvement for memory and cognition, for mood stabilization in adolescent males and in preventing epileptic seizures in children:
‘Akhondian et al demonstrated that treatment of intractable pediatric seizures with water extract of black seed (40 mg/kg/8 h) versus placebo, as an adjuvant therapy to anti-epileptic drugs, led to a significant reduction in the mean frequency of seizures [80]. A similar clinical trial done by the same author had similar outcomes, although TQ (1 mg/kg) was administered as an add-on therapy instead of water extract of black seed [81]. On the other hand, another study conducted by Shawki et al had a different result; after administration of 40 – 80 mg/kg/day of black seed oil as an adjuvant therapy for 4 weeks, no beneficial effects on the frequency and severity of seizures in intractable epileptic children were observed [82].
In a placebo-controlled clinical trial addressing memory and cognition, healthy elderly volunteers took a 500-mg NS capsule twice a day over a period of 9 weeks [83]. At the end of that period, through special tests, the authors observed improved cognition, memory, and attention. Similarly, another CT performed on healthy adolescent males aged 14 to 17 years established the modulatory effects on cognition, mood, and anxiety of NS taken in the form of a 500-mg NS capsule once a day for four weeks [84].
Sangi et al introduced NS administration as a effective non-opiate treatment for opioid dependence [85]. They found that NS treatment offers some advantages in contrast with opiate treatments, such as relieving the withdrawal effects, maintaining the physiological parameters, and improving appetite. Table 2.’
Black seed oil is more powerful than pharmaceutical analgesics (painkillers) used topically for mastalgia
‘Huseini et al showed that as compared with the topical administration of diclofenac, topical administration of NS oil had significant therapeutic effects on patients with cyclic mastalgia without any adverse effects [86]. In that study, 600 mg of NS oil (in the first treatment group) and 20 mg of topical diclofenac (in the second treatment group) were applied to the painful area twice daily for two months.’
7/ Black seed oil helps vitiligo and eczema
‘Vitiligo is an autoimmune skin disease occurring due to the destruction of skin melanocytes that produce skin pigment. A RCT comparing the efficacy of applying NS oil and fish oil to the lesions of vitiligo twice a day for six months indicated that the former is more effective than the latter in reducing the size of the lesions [39].
Hand eczema is a pruritic papulovesicular dermatitis severely influencing the patient’s quality of life. Yousefi et al compared the effects of NS ointment, betamethasone, and eucerin on the severity of hand eczema and the patients’ quality of life [87]. In that study, for new cases of hand eczema in patients between 18 and 60 years of age the mentioned drugs were applied twice daily for 4 weeks. Through particular measures, the authors concluded that NS may be as effective as betamethasone in enhancing quality of life and alleviating the severity of eczema and that both were more effective than eucerin.
In contrast, for a comparison of the therapeutic effects of NS oil ointment and aplacebo on patients with atopic dermatitis (eczema), 20 patients were asked to apply NS oil on one arm and a placebo on the other every day for 4 weeks [88]. The authors of that study reported that no meaningful difference could be found in terms of the parameters measured, e.g., severity, pruritis, transepidermal water loss, and skin hydration, between the treatment with NS oil ointment and with a placebo.
Arsenical keratosis manifests itself in both the palms of the hands and the soles of the feet due to chronic arsenic consumption caused by drinking contaminated water. Taking capsules of NS oil (500 mg) and vitamin E (200 mg) for eight weeks has been shown to reduce the body’s arsenic load, thereby contributing to an overall alleviation of the symptoms in patients with this disease [89].’
8/ What criminals pharma and the media are in suppressing those info. Black seed oil eased liver damage and assisted ‘seroreversion’ in HIV patients.
Reduction of viral load to ‘undetectible’, the goal of many HIV patients per Andrew Sullivan.
‘Onifade et al confirmed that treatment of a sero-positive human immunodeficiency virus (HIV) infected man with NS concoction (10 mL twice/day for six months) resulted in the reduction of the viral load to an undetectable level in 3 months, an elevation of the CD4 count, an alleviation of the symptoms, and a sustained sero-reversion [91]. Similarly, another study conducted by the same author on a sero-positive HIV infected woman revealed the efficacy of NS and honey therapy (10 mL thrice/day for 1 year) for sustained sero-reversion [92]. These effects can be ascribed to the probable virucidal activity of NS [91]’
9/ Black seed oil for ulcers and gastritis (I had those symptoms once and the hospital prescribed a proton pump inhibitor with horrific side effects listed. I never took it and my symptoms are now completely gone.)
‘The helicobacter pylori (H. pylori) bacterium can cause many diseases, such as peptic ulcers and gastric cancer. Infection with H. pylori has a high prevalence worldwide. Salem et al stated that in a four-week course, the efficacy of NS powder (2 g/day) administered together with omeprazole to eradicate an H. pylori infection in non-ulcer dyspeptic patients was relatively the same as that of triple therapy, although 1 g/day or 3 g/day of NS powder given together with omeprazole was not as effective, indicating that the optimal dose of NS was 2 g/day [93]. (Triple therapy includes clarithromycin, amoxicillin, and omeprazole.)’
10/ Infertile men’s sperm motility boosted and positive effect on Leydig cells where male hormones are manufactured. A possible treatment for the feminization of men from many sources now?
‘Reproductive system
Kolahdooz et al proved that treatment of infertile Iranian men with 2.5 mL of NS oil twice a day for two months, in contrast with a placebo treatment in the same manner, could enhance sperm parameters, including sperm count, motility and morphology, semen volume, pH, and its round cells [41]. Other beneficial effects of NS on Leydig cells, reproductive organs, and sexual hormones in infertile men have also been confirmed [95].’
11/ Black seed oil for allergies and asthma:
‘As for lower respiratory tract illnesses (LRTI), Boskabady et al investigated the antiasthmatic effects of NS boiled extract (50 and 100 mg/kg), theophylline (5 mg/kg), and salbutamol (200 μg) [96]. In that study, 15 asthmatic patients were recruited, and each patient received one of these 4 treatments in random order at intervals of 48 hours for 2 weeks. The results of that study demonstrated that in spite of the fact that both doses of NS boiled extract showed bronchodilatory effects, their efficacies for pulmonary function test (PFT) elevation were less than those of theophylline and salbutamol. The results also revealed the prophylactic effects of NS boiled extract on adult asthmatic patients. In another study, over a 3-month period, the daily intake of 15 mL/kg of 0.1% NS boiled extract led to more impressive improvements in the PFT parameters and alleviations of the symptoms of asthma than the intake of the placebo solution did [97]. Ahmad et al conducted a study on 5- to15-year-old LRTI patients with wheezing and investigated the beneficial impacts of the standard treatment alone and the standard treatment combined with the use of NS oil [98]. The authors of that study concluded that the standard treatment when administered with NS oil (0.1 mg/kg for 14 days) had more beneficial effects in reducing the pulmonary index and improving the peak expiratory flow rate [98]. In another study, daily administration of 0.375 mL/kg of 50% NS boiled water extract, as compared with a placebo solution to victims of chemical warfare, as compared with a placebo solution, for two months effected meaningful improvements in the PFT measures and the respiratory symptoms, indicating that the use of NS had a prophylactic impact on victims of chemical warfare [99].
Allergic rhinitis (AR) is an inflammatory response of the nasal mucosa to natural allergens and is characterized by sneezing, rhinorrhea, nasal congestion, and itching [47, 100]. Moreover, a study comparing the therapeutic effects of NS seeds (250 mg/day) and montelukast (10 mg/day) on patients with seasonal allergic rhinitis over a course of two weeks illustrated that both improved the daytime and ophthalmic symptoms considerably, although NS was more efficient in alleviating the nighttime symptoms [46]. Similarly, Nikakhlagh et al showed the positive effects of NS oil capsule consumption over four weeks on the symptoms of allergic rhinitis, i.e., nasal mucosal congestion, nasal itching, runny nose, sneezing attacks, turbinate hypertrophy, and mucosal pallor [100]. Like the previous studies, that of Alsamarai et al demonstrated that nasal drops of NS oil, in comparison with nasal drops of ordinary food oil, could significantly improve the symptoms of AR patients, as well as their ability to tolerate exposure to allergens [47]. In that study, each drop comprised 15 mL of oil, and the patients applied 2 drops nasally (one in each nostril) 3 times daily for 6 weeks. In an additional study of AR patients who underwent a month of allergen-specific immunotherapy and then received treatment with NS seeds (2 g/d) during the next month, in contrast with the AR patients who only received immunotherapy for two months, the former showed more progress in their immune status, e.g., PMN functions and CD8 counts [101]. That study showed that NS administration contributed to a more effective immunotherapy. According to a study by Oysu et al, some of the nasal symptoms of geriatric patients, for example, nasal dryness, obstruction, and crusting, can be significantly improved by using NS oil [102].’
12/ Black seed oil notably improved rheumatoid arthritis
‘Rheumatoid arthritis (RA) is a chronic systemic disease characterized by inflammation of the joints, degeneration of collagen fibers in mesenchymal tissues, and atrophy of bones. Although the etiology is not well understood, autoimmunity seems to play a role in the etiology of RA. A study on 40 female RA patients who received placebo capsules twice a day in the first month and 500-mg NS oil capsules twice a day in the next month observed that the use of NS oil capsules notably improved the disease’s activity score and alleviated its symptoms, which could be attributed to the modulatory effect of NS on the immune system [104].’
13/ Black seed oil for dyspepsia, gastritis (again) and celiac disease.
‘Celiac disease (CD) is characterized by increased sensitivity to gluten and by inflammation and destruction of the small intestine mucosa due to an autoimmune mechanism. In a study by Osman et al, the prescription of a gluten free diet (GFD) together with the consumption of a NS oil capsule (450 mg) twice daily as dietary supplement for one year was more effective than a GFD alone in the treatment of patients with iron deficiency anemia associated with refractory CD; i.e., the hematological and immunological indices and the duodenal histology recovery were improved [106]. Dermatitis herpetiformis (DH) is an autoimmune skin disease caused by CD and is characterized by itchiness, a burning sensation, and chronic dermatitis. Similar to the former CT, adding NS oil capsules to a GFD for a period of 6 months was found to enhance the efficacy of a GFD in the treatment of the disease [107]. Furthermore, Mohtashami et al. reported that administration of a honey-based formulation of NS oil (5 mL NS oil/day), in comparison with a placebo, for 8 weeks could significantly improve the symptoms, such as dyspepsia severity, and decrease the rate of H. pylori infection in functional dyspeptic patients [42].’
15/ The authors summarize all the conditions that are improved or healed per peer reviewed studies, by black seed oil. They recommend studies that confirm all of these existing studies so black seed oil can be used in treatment protocols for HIV, epilepsy, leukemia, male infertility, gastritis, asthma, allergies, menopausal symptoms, high cholesterol, and skin diseases. Of course these were not forthcoming as I am seeing that Pharma’s method is to discourage confirmatory studies after evidence of healing substances are found initially by scientists.
‘This review article summarized different studies on the clinical uses of NS and TQ in the prevention and the treatment of different diseases. Results indicated that NS has beneficial effects when used in the therapies for various diseases, including cardiovascular, nervous system, skin, infectious, reproductive system, respiratory system, skeletal system, and gastrointestinal diseases. Taken together, the role of NS in the treatment of different diseases is discussed in the following sentences.
Dyslipidemia plays an important role in the genesis of cardiovascular diseases (CVDs) [71], and hypercholesterolemia is the most important risk factor for atherosclerosis [72]. Lipid abnormalities are accountable for 56% of patients with heart disease and 18% of those with an infarction; further, it is associated with one third of deaths worldwide. In this article, we reviewed 19 clinical trials that reported the ameliorative effect of NS on the lipid profile. This finding shows that the use of NS supplements can improve the lipid profile and prevent CVDs both in healthy people and hyperlipidemic patients. The exact mechanisms of the lipid-modifying effects of NS are not known, but might be associated with the inhibition of intestinal cholesterol absorption, decreased hepatic cholesterol synthesis, and up-regulation of LDL receptors [74].
On the other hand, dyslipidemia is an important risk factor responsible for cardiovascular disease in patients with diabetes [109], so alleviation/elimination of lipid abnormalities is important in the prevention of the complications of diabetes [79]. Thus, keeping the lipid profile of diabetic patients in the normal range can improve their health status, and NS intake, in combination with anti-diabetics and statins or fibrates, can help diabetic patients to control both dyslipidemia and blood sugar. We also reported the results of 13 clinical trials that presented data on the hypoglycemic effect of NS, 8 of which included patients with insulin resistance. The results showed that the use of black seed could decrease the HbA1c (5 studies) and the PPBG (2 studies) levels significantly.
Obesity is typically associated with increased risk factors of CVDs. Therefore, a therapeutic approach that aims to control body weight and the metabolic profile might be effective in preventing CVDs [62]. The results of this review demonstrate that the use of NS may have a weight-lose effect in obese men and women. Because of the lipid-modifying, hypoglycemic, and weight-lowering effects of black seed, its use in the treatment of patients with metabolic syndrome may be beneficial [21].
According to some studies reviewed, NS may be a useful herb for improving sexual function because of its inhibitory effect on prolactin [51] and excitatory effect on testosterone [33]. In addition, spermatogenesis can be stimulated by NS [95]. Consequently, it presents a good option for use in the treatment of infertile men. However, more studies are needed due to the lack of an adequate number of studies proving this effect.
TQ has an antioxidant role, improves the body’s defense system, induces apoptosis, and controls the Akt pathway [7]. Immune system modulation is one of the most important properties of NS, and a number of studies have been done in order to prove this significant effect. In this article, we reviewed five studies that directly showed the immuno-modulatory effect of NS.
15/ The authors summarize all the conditions that are improved or healed per peer reviewed studies, by black seed oil. They recommend studies that confirm all of these existing studies so black seed oil can be used in treatment protocols for HIV, epilepsy, leukemia, male infertility, gastritis, asthma, allergies, menopausal symptoms, high cholesterol, and skin diseases. Of course these were not forthcoming as I am seeing that Pharma’s method is to discourage confirmatory studies after evidence of healing substances are found initially by scientists.
‘This review article summarized different studies on the clinical uses of NS and TQ in the prevention and the treatment of different diseases. Results indicated that NS has beneficial effects when used in the therapies for various diseases, including cardiovascular, nervous system, skin, infectious, reproductive system, respiratory system, skeletal system, and gastrointestinal diseases. Taken together, the role of NS in the treatment of different diseases is discussed in the following sentences.
Dyslipidemia plays an important role in the genesis of cardiovascular diseases (CVDs) [71], and hypercholesterolemia is the most important risk factor for atherosclerosis [72]. Lipid abnormalities are accountable for 56% of patients with heart disease and 18% of those with an infarction; further, it is associated with one third of deaths worldwide. In this article, we reviewed 19 clinical trials that reported the ameliorative effect of NS on the lipid profile. This finding shows that the use of NS supplements can improve the lipid profile and prevent CVDs both in healthy people and hyperlipidemic patients. The exact mechanisms of the lipid-modifying effects of NS are not known, but might be associated with the inhibition of intestinal cholesterol absorption, decreased hepatic cholesterol synthesis, and up-regulation of LDL receptors [74].
On the other hand, dyslipidemia is an important risk factor responsible for cardiovascular disease in patients with diabetes [109], so alleviation/elimination of lipid abnormalities is important in the prevention of the complications of diabetes [79]. Thus, keeping the lipid profile of diabetic patients in the normal range can improve their health status, and NS intake, in combination with anti-diabetics and statins or fibrates, can help diabetic patients to control both dyslipidemia and blood sugar. We also reported the results of 13 clinical trials that presented data on the hypoglycemic effect of NS, 8 of which included patients with insulin resistance. The results showed that the use of black seed could decrease the HbA1c (5 studies) and the PPBG (2 studies) levels significantly.
Obesity is typically associated with increased risk factors of CVDs. Therefore, a therapeutic approach that aims to control body weight and the metabolic profile might be effective in preventing CVDs [62]. The results of this review demonstrate that the use of NS may have a weight-lose effect in obese men and women. Because of the lipid-modifying, hypoglycemic, and weight-lowering effects of black seed, its use in the treatment of patients with metabolic syndrome may be beneficial [21].
According to some studies reviewed, NS may be a useful herb for improving sexual function because of its inhibitory effect on prolactin [51] and excitatory effect on testosterone [33]. In addition, spermatogenesis can be stimulated by NS [95]. Consequently, it presents a good option for use in the treatment of infertile men. However, more studies are needed due to the lack of an adequate number of studies proving this effect.
TQ has an antioxidant role, improves the body’s defense system, induces apoptosis, and controls the Akt pathway [7]. Immune system modulation is one of the most important properties of NS, and a number of studies have been done in order to prove this significant effect. In this article, we reviewed five studies that directly showed the immuno-modulatory effect of NS.
15/ The authors
16/ This summary article cites dozens of studies and it was publisher in 1992. Of course the 30 years that followed did NOT follow up on these breakthrough findings and this the billions in pharma treatments, with their gruesome side effects, for menopause, make infertility, asthma, gastritis, metabolic syndrome, diabetes, heart disease, leukemia, epilepsy and HIV, were protected.
Study:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633670/
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